- Alpha-glycosylrutin, ascorutin, benzopyrone, Birutan Forte, buckwheat (Fagopyrum esculentum), dihydroxyethylrutoside, eldrin, Ercevit fort, ergot compound, essaven, flavanoid, Fleboside, Globulariacitrin, Globularicitrin, glucopyranoside, HR, hydrolytic enzymes (HE), hydroxyethyl rutoside, hydroxyethylrutosiden, ilixanthin, melin, myrticalorin, myrticolorin, myticolorin, osyritrin, oxyritin, oxerutin, paliuroside, ParovenÂ® (UK, S. Africa, Australasia), paveron 75, phlebolan-spray, phlebotropic drugs, phytomelin, Q1, quercetin, quercetin rutinoside, RelveneÂ® (France), rexiluven (DRA 363, Sandoven), ritmilen, rutabion, rutin trihydrate, rutinic acid, rutinion acid, rutosid, rutoside, rutozyd, sandoven, sophorin, tanrutin, tetrahydroxyethyl-quercitin, tetrahydroxyethylrutoside, tri-(hyroxyethyl)-rutin, trihydroxyethylrutoside (“varemoid”), trioxyethylrutin, troxerutin (CAS 7085-55-4), trypsin, VenorutonÂ® (most of Continental Europe), Venoruton 1000Â®, Venoruton ForteÂ®, vicalin, violaquercitrin, vitamin P.
- Rutin is a yellow crystalline flavonol glycoside (C27H30O16) that occurs in various plants (rue, tobacco, buckwheat, etc.). Upon hydrolysis (a chemical reaction that uses water to break down a compound), rutin yields quercetin and rutinose.
- Rutin is used in many countries as a vasoprotectant and is an ingredient in numerous multivitamin preparations and herbal remedies. The rutosides are naturally occurring flavonoids that have documented effects on capillary permeability and edema (swelling) and have been used for the treatment of disorders of the venous and microcirculatory systems.
- There is some evidence for the use of rutin for chronic venous insufficiency, edema, hemorrhoids, microangiopathy (disease of small blood vessels), varicosis and venous disorders. Well presented clinical trials are required in these fields before solid recommendations can be made.
- Formulations, mainly consisting of the trihydroxyethyl derivative of rutin, are used in Europe, Mexico and other Latin American countries for the treatment of such venous disorders as varicose veins and hemorrhoids. The generic name for these formulations is troxerutin. Troxerutin has been widely used in Europe since the mid-1960s.
These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.
Overall, the results suggest a benefit for O-(beta-hydroxyethyl)-rutosides in chronic venous insufficiency. Additional study is needed to confirm these findings.
Overall, the results suggest a benefit for various rutin compounds in reducing edema and flight edema. Better-designed studies are needed to confirm these results.
Preliminary evidence suggests that o-(beta-hydroxyethyl) rutosides and trihydroxyethylrutosides may be safe and effective treatments for hemorrhoids. Studies investigating the effect of rutin in different populations, as well as efficacy on third or fourth degree hemorrhoids are warranted in future studies.
One clinical trial supported the use of O-(beta-hydroxyethyl)-rutosides for reduction of symptoms associated with Meniere’s syndrome. Additional study is warranted in this area.
Overall, the results suggest a benefit for O-(beta-hydroxyethyl)-rutosides in microangiopathy (disease of the small blood vessels). Better-designed clinical trials in this field are required before a firm recommendation can be made.
One well designed clinical trial has been conducted in the area of retinal vein occlusion. Further well designed studies are required in this field before a firm recommendation can be made.
Preliminary evidence does not suggest that tri-(hydroxyethyl)-rutin offer benefits to retinopathy patients. Well-designed studies in this field are required before a firm recommendation can be made.
One well designed study suggests that O-[beta-hydroxyethyl]-rutosides may offer benefit in terms of schizophrenia. More studies are required in this area before a strong recommendation can be made.
In one clinical trial, O-(beta-hydroxyethyl)-rutoside offered benefit in terms of skin irritation to individuals with breast cancer undergoing radiation treatment. Additional study is needed in this area
Superficial vein thrombosis (SVT) is a common complication of varicose veins. One clinical trial suggests that VenorutonÂ®, in combination with elastic compression or thrombectomy, offers benefit as compared to these treatments alone. Additional study is needed in this area.
Rutin, in combination with compression, appears to have benefit over compression alone in the treatment of varicose leg ulcers. However, results are conflicting. Additional study is needed in this area.
Overall, the evidence suggests a benefit of troxerutin or O-(beta-hydroxyethyl) rutoside for varicosis. Well-designed clinical trials are required before a firm recommendation can be made.
Overall, the results suggest a benefit of hydroxyethylrutosides for venous hypertension (high blood pressure). Additional study is needed in this area.
*Key to grades:
The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.
Adults (18 years and older)
- There are various preparations of rutin used in clinical trials, including capsules, sachets and injections. Various dosages of hydroxyethylrutosides (HR) have been used, including 500 milligrams twice per day and 250-300 milligrams three to four times per day for 28 days. The most commonly used dose by mouth is 1-2 grams of rutin per day in divided doses for four weeks. However, up to 3,500 milligrams has been studied in clinical trials. Rutin has also been taken as trihydroxyethylrutosides (troxerutin) and oxerutin. Brand name products studied include VenorutonÂ® and ParovenÂ®.
- VenorutonÂ® 1 gram three times daily is a commonly used dose in combination with elastic compression for eight weeks to treat superficial vein thrombosis or flight edema.
- Troxerutin is typically taken in higher doses of 3,500-7,000 milligrams per day in divided doses for up to four months. To treat venous insufficiency in premenstrual and pregnant women, 4 grams daily troxerutin has been given for four months.
- One 300-milligram tablet of trihydroxyethylrutosides twice daily for up to four weeks has been used for hemorrhoids. However, 500-4,000 milligrams HR given by mouth twice daily in the treatment of first-, second-, or third-degree hemorrhoids is more commonly used.
- For schizophrenia, 3 grams per day of a mixture of O-[beta-hydroxyethyl]-rutosides (ParovenÂ®/VenorutonÂ®) for three months has been used.
- A single injection of 1,000 milligrams HR followed by 500 milligrams three times per day by mouth for four weeks has been used for chronic venous insufficiency. Injections should only be given under the supervision of a qualified healthcare professional, including a pharmacist.
Children (under 18 years old)
- There is no proven safe or effective dose of rutin in children.
The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.
- Avoid in individuals with a known allergy or hypersensitivity to O-(beta-hydroxyethyl)-rutosides or plants that rutin is commonly found in, such as rue, tobacco or buckwheat. One case of leg dermatitis was noted in an elderly patient while taking O-(beta-hydroxyethyl)-rutosides.
Side Effects and Warnings
- Rutins, oxerutins and troxerutins have been used effectively and safely in several clinical and equivalence trials. Numerous reports have reported no adverse side effects with rutin treatment. Laboratory findings were noted as unchanged. Few adverse effects have been reported, most of which were mild or transient. Rutin is possibly unsafe when taken in very high doses for long periods of time.
- Adverse effects reported while taking O-(beta-hydroxyethyl)-rutosides have included monocytosis, eosinophilia (increased white blood cell count), deep vein thrombosis, superficial thrombophlebitis, skin rash, hair loss, gastritis (stomach inflammation), vomiting, diarrhea, constipation, dry mouth, abdominal pain, headache, acute brain syndrome, dizziness, sleeping problems, tiredness, swelling, muscle stiffness, and upper respiratory tract infection.
- Use cautiously in elderly patients; most adverse effects have been reported in elderly populations.
- Use cautiously in individuals with skin conditions; dermatitis has been noted with use.
Pregnancy and Breastfeeding
- Rutin supplements have been safely used during pregnancy to treat venous insufficiency, hemorrhoids, and varicose veins. Consult with a qualified healthcare professional, including a pharmacist, before taking rutin to make sure that the benefits of rutin supplementation outweigh the risks in each individual. Rutin is not recommended in breastfeeding women due to a lack of available scientific evidence.
The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.
Interactions with Drugs
- Rutin is often used in combination with coumarin. Caution is advised in patients with bleeding disorders or taking drugs that my increase the risk of bleeding. Dosing adjustments may be necessary.
- PhlogenzymÂ® tablets (a combination product containing rutin) have been used with antibiotics. In theory, rutin should be safe to combine with antibiotics.
- Theoretically, rutin may have additive effects when used in combination with benzopyrones, anti-edema drugs, WobenzymÂ® (contains rutin), DicynoneÂ® or ReparilÂ®.
- Intramuscular administration of the fixed combination of troxerutin and carbazochrome has been well-tolerated in improving hemorrhoidal and post-surgical symptoms during the five days following surgery. Injections should only be given under the supervision of a qualified healthcare professional, including a pharmacist.
- Theoretically, rutin may have additive effects when used in combination with diuretics. Caution is advised.
- Taking hydroxyethylrutoside by mouth may counteract docetaxel-fluid retention.
- N-acetylcysteine (NAC) in combination with rutin may reduce ethane and MDA concentrations, and increase GSH; this combination may be efficient in protecting the lungs of patients with adult respiratory distress syndrome.
- High doses of O-(beta-hydroxyethyl)-rutosides may counteract the unwanted activity of birth control pills on venous function.
- Theoretically, rutin may competitively inhibit action of quinolone antibiotics, which are used in the treatment of malaria.
Interactions with Herbs and Dietary Supplements
- Oxerutins may have an additive effect when used concomitantly with horse chestnut extract.
- Rutosid enzyme is often used in combination with bromelain and trypsin. Based on early evidence, troxerutin appears safe for use with Gingko bilobo for the treatment of hemorrhoids.
- N-acetylcysteine (NAC) in combination with rutin may reduce ethane and MDA concentrations and increase GSH; this combination may be efficient in protecting the lungs of patients with adult respiratory distress syndrome.
- Rutin supplements may have an additive effect with quercetin supplements, as quercetin is a flavonoid yielded from rutin.
- Theoretically, rutin may increase absorption of vitamin C. Rutin is found in buckwheat herb tea and thus may have an additive effect when taken concomitantly.
Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.
- This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ().
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Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.