Alternate Title

  • Pancreatic enzymes

Related Terms

  • Aczym, amylase, Berizym®, bovine pancreatin, Cotazyme-S®, Cotazyme-S-Forte®, Cotazyn®, Creon®, Digepepsin®, Dizymes®, Donazyme®, Elzyme®, Entolase-HP®, Entozyme®, Hi-Vegi-Lip®, Hyperzym®, Kreon®, Lypase®, Maxamase HL-16®, Nortase®, Panar®, pancrease, Pancrease®, Pancrease MT4®, Pancrease MT10®, Pancrease MT16®, pancreatic acid, Pancreatin enseals®, Pancreatin® Merck, pancreatinum, pancreatis pulvis, pancrelipase, Pancrex®, Pancrex-Duo®, Pancrex V®, Pancrex V® Forte, Pankreoflat®, Pankreon®, Panteric®, Panzytrat®, PEP, procine pancreatin, protease, Ultrase MT12®, Ultrase MT20®, Ultrase MT24®, Viokase®, Zymase®.
  • Select combination products: FZ 560 (fentonium bromide 10mg, dehydrocholic acid 25mg, pancreatin 3FU 50mg, and lactulose 200mg).


  • Pancreatin consists of enzymes from cow or pig pancreas, namely amylase, protease, and lipase, which digest starch, protein, and lipids, respectively. Historically, pancreatic enzyme preparations were available over-the-counter (OTC); however, due to problems associated with their use, the U.S. Food and Drug Administration (FDA) now requires manufacturers to obtain FDA approval before they can market and sell their pancreatin product.
  • Pancreatin and pancrelipase share similar functions and indications; however, pancrelipase contains a more concentrated extract than pancreatin. Pancrelipase is found in FDA-approved pancreatic enzyme replacement therapy (Creon®, Zenpep, Pancreaze®, etc.). Pancrelipase contains 12 times the lipase activity, four times the amylase activity, and four times the protease activity of conventional pancreatin.
  • In the United States, most pancreatic enzyme preparations are prescribed for patients with pancreatic digestive enzyme insufficiency from cystic fibrosis or chronic pancreatitis (inflammation of the pancreas). The efficacy of pancreatic enzyme supplements is widely accepted for these conditions.
  • Pancreatic enzymes are used in modern medicine mainly for treating exocrine pancreatic insufficiency, a condition in which food is not properly digested because the pancreas does not make an adequate amount of digestive enzymes. Other potential uses, which have less supportive evidence, include immune stimulation, tissue repair, blood clot treatment, and as a general digestive aid.

Evidence Table


    These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

    Digestive enzyme/pancreatic insufficiency

    Enzyme replacement therapy is commonly used for patients with digestive enzyme insufficiency associated with cystic fibrosis or chronic pancreatitis (pancreatic inflammation). The safety of pancreatin, especially high-dose use in children, is not well-documented. Further research is needed to completely evaluate the safety and efficacy of pancreatin.

    Hernia (hiatal hernia complex)

    Hiatal hernia complex is a condition characterized by symptoms including enlarged stomach, gas, and expulsion of gas. Limited study suggests that pancreatin may be effective in reducing these symptoms; however, additional studies are needed to confirm these preliminary findings.

    Recovery from surgery (pancreatic, gastrectomy)

    Results of preliminary human study show that pancreatin may improve symptoms of maldigestion after partial or total surgical removal of the pancreas (pancreatectomy) or stomach (gastrectomy). Additional research is needed.


    There is fair negative evidence that argues against pancreatin use in diabetic patients. Some study showed a lack of effect of pancreatin on blood glucose levels. In another study, switching from pancreatin treatment to mock treatment and vice-versa resulted in impaired regulation of blood glucose levels, including low blood sugar.

    Pain (chronic pancreatitis)

    Pancreatic enzyme supplements have been used for pain relief from chronic pancreatitis (inflammation of the pancreas). The available evidence indicates a lack of benefit from pancreatin; however, additional study is required to confirm these initial findings.

*Key to grades:



    The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.



    The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

  • Adults (18 years and older)

    • Dosing of pancreatic enzymes is patient-specific. Pancreatic enzymes should be taken by mouth at the beginning of meals. A typical starting dose of pancreatin is 8,000-24,000 USP units of lipase taken by mouth.
    • For pancreatic insufficiency, Creon®, Zenpepâ„¢, and Pancreaze® are FDA-approved pancreatic enzyme replacement products.
    • For digestion of a regular meal, 25,000-40,000 units of lipase activity are required in the intestine to prevent lipid malabsorption; due to the rapid inactivation of lipase, up to 10 times that amount must be taken by mouth.
  • Children (under 18 years old)

    • There is no proven safe or effective dose of pancreatin in children.



    The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

  • Allergies

    • Avoid in patients with known allergy/hypersensitivity to pancreatin, pancreatin components, or pork protein.
    • Pharmacy employees have had an immune response (IgE) against pig and cow trypsin from pancreatic powder.
    • Parents of children with cystic fibrosis have developed immediate hypersensitivity and allergic symptoms (anaphylaxis, asthma, cough, rhinoconjunctivitis, wheezing) to pancreatic extract.
  • Side Effects and Warnings

    • Pancreatin supplements should be used only on the advice of a medical practitioner.
    • Pancreatin is likely safe when taken by mouth in doses recommended by a healthcare practitioner for patients with exocrine pancreatic insufficiency, a condition in which food is not properly digested because the pancreas does not make an adequate amount of digestive enzymes.
    • Side effects may include abdominal pain, allergic reactions, altered glucose control, anaphylaxis (life-threatening allergic reaction), asthma, asthmatic symptoms, bronchial asthma, colon wall thickening, skin irritation, skin reactions (pruritic erythema with eosinophilia), cough, dry mouth, gastrointestinal symptoms (bloating, constipation, diarrhea, colonic obstruction, gas, gastrointestinal upset and pain, fibrosing colonopathy (a complication of cystic fibrosis), fibrotic colonic strictures, meconium ileus, and steatorrhea (fatty stool)), headache, infections, kidney side effects (hyperuricosuria and crystalluria), stuffy nose, pneumothorax (air leakage into the space between the lungs and the chest wall), watery eyes, ulcerative colitis (a type of inflammatory bowel disease) with colorectal erythema and hematochezia, and wheezing.
    • Pancreatin may affect blood glucose levels. Caution is advised in patients with diabetes or hypoglycemia, or in those taking drugs, herbs, or supplements that affect blood sugar. Blood glucose levels may need to be monitored by a qualified healthcare professional, including a pharmacist, and medication adjustments may be necessary.
    • Use with caution in patients at risk for developing headaches or with a history of migraines, or in patients with gastrointestinal, lung, respiratory, or kidney disorders.
    • Use with caution in patients using calcium carbonate- or magnesium hydroxide-containing antacids, folic acid, or iron.
    • Avoid in patients with allergy or hypersensitivity to pancreatin, pork protein, or any other components of pancreatin.
    • Avoid in pregnant or breastfeeding women due to a lack of scientific evidence.
  • Pregnancy and Breastfeeding

    • There is a lack of available medical evidence on the safety or effectiveness of pancreatin in pregnant and breastfeeding women.



    Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

  • Interactions with Drugs

    • Pancreatin may lower blood sugar levels. Caution is advised when using medications that may also lower blood sugar. Patients taking drugs for diabetes by mouth or insulin should be monitored closely by a qualified healthcare professional, including a pharmacist. Medication adjustments may be necessary.
    • Pancreatin may also interact with antacids, anticancer drugs, dehydrocholic acid, dimethylpolysiloxane, fentonium chloride, folic acid, H2 blockers, iron salts, lactulose, misoprostol, painkillers, and proton pump inhibitors (PPIs).
  • Interactions with Herbs and Dietary Supplements

    • Pancreatin may lower blood sugar levels. Caution is advised in patients using herbs and supplements that may also lower blood sugar. Blood glucose levels may need monitoring, and doses may need adjustment.
    • Pancreatin may also interact with acid-containing foods, alkaline foods, antacids, anticancer agents, bromelain, fat-soluble vitamins (A, D, E, K), folate, folic acid, foods high in folic acid, high calorie diets, iron, iron-containing foods, painkillers, picolinic acid, zinc, and zinc-containing foods.


  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ().



    Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.

  • Brady MS, Rickard, K, Yu PL, et al. Effectiveness and safety of small vs. large doses of enteric coated pancreatic enzymes in reducing steatorrhea in children with cystic fibrosis: a prospective randomized study. Pediatr Pulmonol 1991;10(2):79-85.
    View Abstract
  • Bruno MJ, Haverkort EB, Tijssen GP, et al. Placebo controlled trial of enteric coated pancreatin microsphere treatment in patients with unresectable cancer of the pancreatic head region. Gut 1998;42(1):92-96.
    View Abstract
  • Chazalette JP. A Double-Blind Placebo-Controlled Trial of a Pancreatic Enzyme Formulation (Panzytrat 25 000) in the Treatment of Impaired Lipid Digestion in Patients with Cystic Fibrosis. Drug Investigation 1993;5(5):274.
  • Ewald N, Bretzel RG, Fantus IG, et al. Pancreatin therapy in patients with insulin-treated diabetes mellitus and exocrine pancreatic insufficiency according to low fecal elastase 1 concentrations. Results of a prospective multi-centre trial. Diabetes Metab Res Rev 2007;23(5):386-391.
    View Abstract
  • Halm U, Loser C, Lohr M, et al. A double-blind, randomized, multicentre, crossover study to prove equivalence of pancreatin minimicrospheres versus microspheres in exocrine pancreatic insufficiency. Aliment Pharmacol Ther 1999;13(7):951-957.
    View Abstract
  • Lancellotti L, Cabrini G, Zanolla L, et al. High- versus low-lipase acid-resistant enzyme preparations in cystic fibrosis: a crossover randomized clinical trial. J Pediatr Gastroenterol Nutr 1996;22(1):73-78.
    View Abstract
  • Lauque S, Nourhashemi F, Baudouin M, et al. Assessment of the effectiveness of drug therapies on nutritional status in the elderly: “concerning a randomised, double-blind clinical study of the activity of pancreatic extracts and a placebo during the renutrition of elderly subjects suffering from protein caloric undernutrition”. J Nutr Health Aging 1998;2(1):18-20.
    View Abstract
  • Layer P and Keller J. Lipase supplementation therapy: standards, alternatives, and perspectives. Pancreas 2003;26(1):1-7.
    View Abstract
  • Malesci A, Gaia E, Fioretta A, et al. No effect of long-term treatment with pancreatic extract on recurrent abdominal pain in patients with chronic pancreatitis. Scand J Gastroenterol 1995;30(4):392-398.
    View Abstract
  • Mossner J, Secknus R, Meyer J, et al. Treatment of pain with pancreatic extracts in chronic pancreatitis: results of a prospective placebo-controlled multicenter trial. Digestion 1992;53(1-2):54-66.
    View Abstract
  • Neoptolemos JP, Ghaneh P, Andren-Sandberg A, et al. Treatment of pancreatic exocrine insufficiency after pancreatic resection. Results of a randomized, double-blind, placebo-controlled, crossover study of high vs standard dose pancreatin. Int J Pancreatol 1999;25(3):171-180.
    View Abstract
  • Patchell CJ, Desai M, Weller PH, et al. Creon 10,000 Minimicrospheres vs. Creon 8,000 microspheres–an open randomised crossover preference study. J Cyst Fibros 2002;1(4):287-291.
    View Abstract
  • Petersen W, Heilmann C, and Garne S. Pancreatic enzyme supplementation as acid-resistant microspheres versus enteric-coated granules in cystic fibrosis. A double placebo-controlled cross-over study. Acta Paediatr Scand 1987;76(1):66-69.
    View Abstract
  • Sarner M. Treatment of pancreatic exocrine deficiency. World J Surg 2003;27(11):1192-1195.
    View Abstract
  • Shin SY, Hur GY, Ye YM, et al. A case of occupational rhinitis caused by porcine pancreatic extract developing into occupational asthma. J Korean Med Sci 2008;23(2):347-349.
    View Abstract