Alternate Title

  • Hepatica

Related Terms

  • Hepatica, Hepatica nobilis, Hepatica transsilvanica, liverleaf, Ranunculaceae (family), sesquiterpene lactone.
  • Note: Liverwort (Hepatica ssp.) should not be confused with Jungermannia ssp., Bazzania ssp., Lepidolaena ssp., Marchantia ssp., Riccardia ssp., Plagiochila ssp., or Frullania ssp., although they are also commonly called liverworts.

Background

    Evidence Table

      Disclaimer

      These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

    *Key to grades:

    Tradition

      Disclaimer

      The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

    Safety

      Disclaimer

      The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

    • Allergies

      • Avoid in individuals with a known allergy or hypersensitivity to liverwort. Liverwort may cause contact hypersensitivity, such as skin rash.
    • Side Effects and Warnings

      • There is very little available information reported on adverse effects. Liverwort is not listed on the U.S. Food and Drug Administration’s Generally Recognized as Safe (GRAS) list. Use cautiously in patients sensitive to liverwort. In a case report, liverwort was associated with contact hypersensitivity.
      • Use cautiously in patients with hypercholesterolemia (high cholesterol) as liverwort may alter lipid levels.
    • Pregnancy and Breastfeeding

      • Liverwort is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

    Interactions

      Disclaimer

      Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

    • Interactions with Drugs

      • Liverwort may alter serum lipid levels (fat levels in the blood). Use cautiously with cholesterol-lowering medications, due to possible additive effects.
    • Interactions with Herbs and Dietary Supplements

      • Liverwort may alter serum lipid levels (fat levels in the blood). Use cautiously with cholesterol-lowering herbs and supplements, due to possible additive effects.

    Attribution

    • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ().

    Bibliography

      Disclaimer

      Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.

    • Knoche H, Ourisson G, Perold GW, et al. Allergenic component of a liverwort: a sesquiterpene lactone. Science 10-10-1969;166(902):239-240.
      View Abstract
    • Storrs FJ, Mitchell JC, Rasmussen JE. Contact hypersensitivity to liverwort and the compositae family of plants. Cutis 1976;18(5):681-686.
      View Abstract
    • Tamehiro N, Sato Y, Suzuki T, et al. Riccardin C: a natural product that functions as a liver X receptor (LXR)alpha agonist and an LXRbeta antagonist. FEBS Lett 10-10-2005;579(24):5299-5304.
      View Abstract