Related Terms

  • Cytokinins, furfural, furfuryladenine, hyaluronidase, isopentenyladenine (IPA), kinerase, kinesin-I, kinetin, kinetin riboside.

Background

  • Kinetin is a chemical analogue of cytokinins, a class of plant hormones that promotes cell division. Kinetin is found in both plants and animals.
  • Scientific studies have investigated whether kinetin might help lower side effects associated with cataract surgery, aid in the treatment of Meniere’s disease or decrease eye blood pressure. Currently, there is not enough scientific evidence to support any of these uses.

Evidence Table

    Disclaimer

    These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

    Cataracts (surgery)

    Side effects of cataract surgery may include pain, infection, swelling, bleeding, or retinal detachment. The use of kinetin during cataract surgery may lower adverse effects associated with cataracts. More research is needed in this area.

    Meniere’s disease

    Meniere’s disease is a disorder of the inner ear, which causes hearing loss, ringing in the ear, and the sensation that one’s surroundings are spinning. Kinetin may be beneficial for patients with Meniere’s disease. However, additional study is needed in this area.

    Ocular disorders (eye blood pressure)

    Kinetin may decrease blood pressure in the eye, although currently there is insufficient available evidence to draw a strong conclusion.

*Key to grades:

Tradition

    Disclaimer

    The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

    Disclaimer

    The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

  • Adults (over 18 years old)

    • There is no proven safe or effective dose for kinetin in adults.
  • Children (under 18 years old)

    • There is no proven safe or effective dose for kinetin in children.

Safety

    Disclaimer

    The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

  • Allergies

    • Avoid in individuals with a known allergy or hypersensitivity to kinetin.
  • Side Effects and Warnings

    • Kinetin may have the following adverse effects: blood thinning effects, increased coagulation (blood clotting) time, inhibited platelet aggregation, and prolonged or increased bleeding.
    • Use cautiously in patients with coagulation or hematologic (blood) disorders or taking anticoagulants or antiplatelets (blood thinners).
  • Pregnancy & Breastfeeding

    • Kinetin is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

Interactions

    Disclaimer

    Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

  • Interactions with Drugs

    • Kinetin may have antioxidant effects. Use cautiously in patients taking antioxidants due to possible additive effects.
    • Kinetin may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, blood thinners such as warfarin (Coumadin®) or heparin, antiplatelet drugs such as clopidogrel (Plavix®), and nonsteroidal anti-inflammatory drugs (NSAIDS) such as ibuprofen (Motrin®, Advil®) or naproxen (Naprosyn®, Aleve®).
    • Kinetin may inhibit cell growth, induce apoptosis, and stimulate cell differentiation. Use cautiously in patients with cancer or taking anticancer agents.
  • Interactions with Herbs & Dietary Supplements

    • Kinetin may have antioxidant effects. Use cautiously in patients taking antioxidant herbs or supplements due to possible additive effects.
    • Kinetin may increase the risk of bleeding when taken with herbs or supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with garlic and saw palmetto.
    • Kinetin may inhibit cell growth, induce apoptosis, and stimulate cell differentiation. Use cautiously in patients with cancer or taking anticancer herbs or supplements.

Attribution

  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ().

Bibliography

    Disclaimer

    Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.

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    View Abstract
  • Barciszewski J, Mielcarek M, Stobiecki M, et al. Identification of 6-furfuryladenine (kinetin) in human urine. Biochem Biophys Res Commun. 12-9-2000;279(1):69-73.
    View Abstract
  • Barciszewski J, Siboska GE, Pedersen BO, et al. Furfural, a precursor of the cytokinin hormone kinetin, and base propenals are formed by hydroxyl radical damage of DNA. Biochem Biophys Res Commun. 9-18-1997;238(2):317-319.
    View Abstract
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    View Abstract
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    View Abstract
  • Hipkiss AR. On the “struggle between chemistry and biology during aging”–implications for DNA repair, apoptosis and proteolysis, and a novel route of intervention. Biogerontology. 2001;2(3):173-178. . View Abstract
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    View Abstract
  • Ishii Y, Hori Y, Sakai S, et al. Control of differentiation and apoptosis of human myeloid leukemia cells by cytokinins and cytokinin nucleosides, plant redifferentiation-inducing hormones. Cell Growth Differ. 2002;13(1):19-26.
    View Abstract
  • Ishii Y, Kasukabe T, Honma Y. Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim.Biophys Acta 9-10-2005;1745(2):156-165.
    View Abstract
  • Ishii Y, Sakai S, Honma Y. Cytokinin-induced differentiation of human myeloid leukemia HL-60 cells is associated with the formation of nucleotides, but not with incorporation into DNA or RNA. Biochim.Biophys Acta 12-7-2003;1643(1-3):11-24.
    View Abstract
  • Kligman D. Cosmeceuticals. Dermatol Clin 2000;18(4):609-615.
    View Abstract
  • Olsen A, Siboska GE, Clark B F, et al. N(6)-Furfuryladenine, kinetin, protects against Fenton reaction-mediated oxidative damage to DNA. Biochem Biophys Res Commun. 11-19-1999;265(2):499-502.
    View Abstract
  • Sheu JR, Hsiao G, Shen MY, et al. Inhibitory mechanisms of kinetin, a plant growth-promoting hormone, in platelet aggregation. Platelets. 2003;14(3):189-196.
    View Abstract
  • Slaugenhaupt SA, Mull J, Leyne M, et al. Rescue of a human mRNA splicing defect by the plant cytokinin kinetin. Hum.Mol.Genet. 2-15-2004;13(4):429-436.
    View Abstract