Alternate Title

  • Galium aparine

Related Terms

  • Acumin, amor-de-hortelã (Portuguese – Brazil), amor de hortelano (Spanish), anthraquinon, aparine (Italian, Portuguese – Brazil), asperuloside, asperulosidic acid, attacca mano (Italian), attacca veste (Italian), aucubin, barweed, bed-straw, bedstraw, Burre-Snerre (Danish), cafeic acid, caglio asprello (Italian), campestrol, catchweed, chlorogenic acid, citric acid, coachweed, cleever, clivers, coumarin, eriffe, erva-pegavosa (Portuguese – Brazil), everlasting friendship, flavonoid, gaillet (French), gaillet gratteron (French), gallotannic acid, Galium aparine, Gewöhnliches Kletten-Labkraut (German), gia mara, glucosides, goosebill, goosegrass, grateron, Grepagras (Norwegian), grip grass, harmine, hashishat al af’a (Arabic), hayriffe, hayruff, hedge clivers, hedgeheriff, iridoid glucosides, iridoidasperulosidic acid, Kaz Yogurtotu (Turkish), Kierumatara (Finnish), Kleber (German), Klebkraut (German), Klebriges Labkraut (German), Kleefkruid (Dutch), Klenge (Norwegian), Klengemaure (Norwegian), Klengjemaure (Norwegian), Kletten-Labkraut (German), Kletternde Labktaut (German), Klifurmaðra (Icelandic), Klimmendes Labkraut (German), Krókamaðra (Icelandic), Krøkin steinbrá (Faroese), loveman, mutton chops, p-coumaric acid, p-hydroxybenzoic acid, pega-pega (Portuguese – Brazil), philanthropon (Greek), Przytulia czepna (Polish), Præstelus (Danish), protopine, Ragadós galaj (Hungarian), Robin-run-in-the-grass, Roomav madar (Estonian), rough bedstraw, Rubiaceae (family), rubichloric acid, saponins, scratweed, silicic acid, sitosterol, SnärjmÃ¥ra (Swedish), SnärmÃ¥ra (Swedish), stickyweed, sticky-willy, stickywilly, stigmasterol, Svízel přítula (Czech), tannins, Tene (Norwegian), Tirmanici yogurtotu (Turkish), Vitblommig snärjmÃ¥ra (Swedish), zhu yang yang (Chinese).
  • Note: Other Galium species, such as Galium spurium L. (False cleavers), will not be discussed in this monograph.

Background

    Evidence Table

      Disclaimer

      These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

    *Key to grades:

    Tradition

      Disclaimer

      The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

    Dosing

      Disclaimer

      The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

    • Adults (18 years and older)

      • Although not well-studied in humans, a version of the red clover combination tea modeled after the Hoxsey formula that contains equal parts red clover, burdock, dandelion root, sarsaparilla, Oregon grape, cleavers, buckthorn, poke, echinacea, licorice, ginger, and wild yam (1 tablespoon of the herbal combination simmered in a cup of boiling water for 10 minutes) has been used at a dosage of 1/2 cup every 1-2 hours for one week.
      • Secondary sources claim that medium-strength doses of cleavers formulated using 2-4g of the dried herb, 2-4mL of a 1:1 25% fluid extract, or 4-10mL of a 5:1 25% tincture, may be taken three times a day.
      • Traditional practitioners have recommended that a tea made from the cleavers plant may be used internally and externally for the treatment of cancer. Other secondary sources claim that the juice of the plant may be more useful than a tea. There is insufficient evidence in humans, however, to support the use of cleavers for any indication.
    • Children (younger than 18 years)

      • There is no proven safe or effective dose for cleavers in children.

    Safety

      Disclaimer

      The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

    • Allergies

      • Avoid in individuals with a known allergy or hypersensitivity to cleavers (Galium aparine), its constituents, or members of the Rubiaceae family.
    • Side Effects and Warnings

      • There is insufficient evidence in humans to support the use of cleavers for any indication, as well as a lack of safety information. Cleavers has traditionally been used as a diuretic and caution is advised in patients taking diuretics or with urinary or renal (kidney) disorders.
    • Pregnancy and Breastfeeding

      • Cleavers is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

    Interactions

      Disclaimer

      Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

    • Interactions with Drugs

      • Although not well studied in humans, cleavers may have diuretic, anti-inflammatory, antigout, antineoplastic, laxative, and hormonal properties. Caution is advised when taking cleavers with other agents that have these effects.
    • Interactions with Herbs and Dietary Supplements

      • Although not well studied in humans, cleavers may have diuretic, anti-inflammatory, antigout, antineoplastic, laxative, and hormonal properties. Caution is advised when taking cleavers with other herbs or supplements that have these effects.

    Attribution

    • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ().

    Bibliography

      Disclaimer

      Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.

    • Deliorman D, Calib Y, Ergun F. Iridoids from Galium aparine. Pharmaceutical Biology 2001;39(3):234-235.
    • Ergun F, Deliorman. D, Velioglu A,. Sener. B. Antimicrobial activities of Galium species. GUEDE J Fac Pharm. Gazi. 1999;16: 7-11.
    • Lans, Turner N, Khan T, et al. Ethnoveterinary medicines used for ruminants in British Columbia, Canada. J Ethnobiol Ethnomed. 2007 Feb 26;3:11. PMID: 17324258
    • Morningstar, H. W. Eat Your Weeds! Sentient Times: Alternatives for Personal & Community Transformation 1999;7(4):14-15.
    • Sener, B. and Ergun, F. Isolation and structural studies on the alkaloids of Galium aparine L. GUEDE J Fac Pharm Gazi 1988;5:33-40.
    • Temizer A, Sayın F, Ergun F, et al. Determination of total flavonoid in various Galium species by differential pulse polarography. 1996.
    • Tierra, M. American Herb Association Quarterly Newsletter 1990;7(2):10.
    • Tzakou O, Couladi MM, Philianos S. Fatty acids and sterols in spring and winter samples of Galium aparine. Fitoterapia 1990;61:93.
    • Wisdom of an Elder: Dr. Douglas Kirkbride. Medical Herbalism: A Journal for the Clinical Practitioner 1996;8(3):14-15.