Alternate Title

  • Eschscholzia californica

Related Terms

  • Eschscholzia californica, Papaveraceae (family).

Background

  • Historically, California poppy has been used as a sedative to relieve insomnia and nervousness.
  • California poppy may bind with the same receptors as monoamine oxidase (MAO) inhibitors and selective serotonin reuptake inhibitors (SSRIs). Caution should be used in patients taking these agents.
  • There is insufficient evidence in humans to support the use of California poppy for any indication.
  • Native Americans used California poppy medicinally.

Evidence Table

    Disclaimer

    These uses have been tested in humans or animals. Safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider.

*Key to grades:

Tradition

    Disclaimer

    The below uses are based on tradition, scientific theories, or limited research. They often have not been thoroughly tested in humans, and safety and effectiveness have not always been proven. Some of these conditions are potentially serious, and should be evaluated by a qualified healthcare provider. There may be other proposed uses that are not listed below.

Dosing

    Disclaimer

    The below doses are based on scientific research, publications, traditional use, or expert opinion. Many herbs and supplements have not been thoroughly tested, and safety and effectiveness may not be proven. Brands may be made differently, with variable ingredients, even within the same brand. The below doses may not apply to all products. You should read product labels, and discuss doses with a qualified healthcare provider before starting therapy.

  • Adults (18 years and older)

    • There is no proven safe or effective dose for California poppy in adults.
  • Children (younger than 18 years)

    • There is no proven safe or effective dose for California poppy in children.

Safety

    Disclaimer

    The U.S. Food and Drug Administration does not strictly regulate herbs and supplements. There is no guarantee of strength, purity or safety of products, and effects may vary. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy. Consult a healthcare provider immediately if you experience side effects.

  • Allergies

    • Avoid in individuals with a known allergy or hypersensitivity to California poppy (Eschscholzia californica) or its constituents.
  • Side Effects and Warnings

    • There are currently no high quality studies available on the medicinal applications of California poppy. California poppy is possibly unsafe when used in patients taking selective serotonin reuptake inhibitors (SSRIs) or monoamine oxidase (MAO) inhibitors.
  • Pregnancy and Breastfeeding

    • California poppy is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

Interactions

    Disclaimer

    Most herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs, or foods. The interactions listed below are based on reports in scientific publications, laboratory experiments, or traditional use. You should always read product labels. If you have a medical condition, or are taking other drugs, herbs, or supplements, you should speak with a qualified healthcare provider before starting a new therapy.

  • Interactions with Drugs

    • Although not well studied in humans, California poppy (Eschscholzia californica) may interact with antidepressant agents, including monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs). Caution is advised in patients taking antidepressants.
    • California poppy may have hypotensive (blood pressure lowering) effects. Caution is advised in patients with hypertension or hypotension and in those taking blood pressuring altering drugs.
    • California poppy may increase the amount drowsiness caused by some drugs. Examples include benzodiazepines such as lorazepam (Ativan®) or diazepam (Valium®), barbiturates such as phenobarbital, narcotics such codeine, some antidepressants, and alcohol. Caution is advised while driving or operating machinery.
  • Interactions with Herbs and Dietary Supplements

    • Although not well studied in humans, California poppy (Eschscholzia californica) may interact with antidepressant herbs or supplements, including monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs). Caution is advised in patients taking herbs and supplements with possible antidepressant or MAOI effects such as 5-HTP, ephedra, hops, St. John’s wort, and vitamin B6.
    • California poppy may have hypotensive (blood pressure lowering) effects. Caution is advised in patients with hypertension or hypotension and in those taking blood pressure altering herbs or supplements. Herbs and supplements with hypotensive effects include black cohosh, flaxseed, garlic, ginger and ginkgo, among others.
    • California poppy may increase the amount of drowsiness caused by some herbs or supplements. Examples may include: 5-HTP, celery, hops, lavender aromatherapy, sage, Siberian ginseng, and St. John’s wort. Caution is advised while driving or operating machinery.

Attribution

  • This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration ().

Bibliography

    Disclaimer

    Natural Standard developed the above evidence-based information based on a thorough systematic review of the available scientific articles. For comprehensive information about alternative and complementary therapies on the professional level, go to . Selected references are listed below.

  • Gafner S, Dietz BM, McPhail KL, et al. Alkaloids from Eschscholzia californica and their capacity to inhibit binding of [3H]8-Hydroxy-2-(di-N-propylamino)tetralin to 5-HT1A receptors in Vitro. J Nat Prod 2006;69(3):432-435.
    View Abstract
  • Meolie AL, Rosen C, Kristo D, et al. Oral nonprescription treatment for insomnia: an evaluation of products with limited evidence. J Clin.Sleep Med 4-15-2005;1(2):173-187.
    View Abstract